Opioids are powerful painkillers that can help manage severe pain, but their long-term use can cause serious harm to the body. One of the organs most affected by opioids is the liver. Understanding the effect of opioids on the liver is important for anyone using these drugs. Here, will explore how opioids can damage the liver, signs of liver damage, and ways to protect this vital organ! If you or someone you know is struggling with opioid use, seeking professional help at a Palm Beach addiction center can provide valuable support
The Importance of the Liver
The liver is one of the most important organs in our body. It performs many vital functions that keep us healthy. One of its main jobs is to filter toxins and harmful substances from our blood. It also helps break down food, turning it into energy that the body can use. The liver produces bile, which is needed to digest food, especially fats. It stores important nutrients like vitamins and minerals, and it helps control cholesterol levels.

In addition to this, the liver plays a role in regulating blood sugar and making proteins that help blood clot when you get a cut. Without a healthy liver, the body cannot function properly. It’s also important to know that the liver can recover from damage, but it needs to be treated with care. Things like drinking too much alcohol, taking certain medications, or having a poor diet can harm the liver over time. Keeping the liver healthy means taking care of your overall health by eating well, exercising, and avoiding things that can cause damage. A healthy liver is essential for living a long and active life.
How Different Opioids Can Affect Your Liver
The effect of opioids on the liver varies depending on the type of opioid used and how long it’s used. We’ve seen many effects on our patients at opioid addiction rehab facility, so here is an overview of how each drug affects you.
Morphine
Morphine is a strong painkiller often used for severe pain relief. While it is effective in managing pain, it can also strain the liver. The liver is responsible for breaking down morphine, and long-term use can lead to liver damage. Overuse of morphine can overwhelm the liver, causing inflammation and increasing the risk of conditions like fatty liver disease. It is important to monitor liver function regularly when using morphine for extended periods.
If you or someone you know is dealing with opioid use, seeking help is very important. Programs like our morphine addiction treatment provide support for individuals struggling with addiction and can help reduce the risk of long-term liver damage.
Oxycodone
Oxycodone is commonly prescribed for managing moderate to severe pain. Although effective, oxycodone can be harsh on the liver, especially when taken in large amounts or for prolonged periods. The liver metabolizes oxycodone, and this process can cause liver stress, leading to liver damage or even failure. Individuals using oxycodone should be cautious about their dosage and avoid mixing it with other substances that also affect liver function, like alcohol.
Hydrocodone
Hydrocodone, like oxycodone, is used to treat pain and cough. When taken in excess, hydrocodone can cause significant liver stress. The liver is responsible for breaking down the drug, and overuse can lead to toxic buildup. This buildup can result in liver injury, especially when hydrocodone is mixed with other medications or alcohol. Chronic use of hydrocodone increases the risk of liver damage, so it is essential to follow medical guidelines when taking this opioid and seek hydrocodone rehab if the addiction gets out of hand.
Codeine
Codeine is a less potent opioid often used to treat mild to moderate pain or cough. While it may seem less harmful, codeine can still affect the liver over time. Like other opioids, the liver processes codeine, and long-term use can cause liver inflammation or more severe liver conditions. If codeine is abused or taken in large doses, it can lead to liver toxicity, so it’s important to use this medication as prescribed and avoid prolonged use.

Long-Term Opioid Use and Liver Damage
As we have seen in many of our patients at partial hospitalization in Palm Beach, any opioid used for an extended period can put stress on the liver. Long-term use of opioids, including morphine, oxycodone, hydrocodone, and codeine, can lead to the accumulation of toxic substances in the liver. This may result in liver diseases like:
- fatty liver
- hepatitis
- cirrhosis
Signs of Liver Damage from Opioid Use
Liver damage from opioids doesn’t always show immediate signs. However, there are some common symptoms to watch for.
Yellowing of the Skin or Eyes (Jaundice)
One of the first signs of liver damage from opioid use is jaundice, which causes the skin or the whites of the eyes to turn yellow. This happens when the liver can’t process bilirubin properly, a substance that builds up when the liver is damaged. Jaundice is often an early warning sign of serious liver issues and should be addressed immediately.
Swelling in the Abdomen or Legs
Swelling in the abdomen or legs can occur when the liver is unable to perform its function of processing fluids. This leads to fluid buildup, known as ascites, especially in the stomach area. If you notice sudden or unexplained swelling, it might be a sign of liver damage, and it’s important to consult a doctor for evaluation and treatment.
Unexplained Fatigue
Chronic fatigue or feeling unusually tired without any clear cause is another sign of liver damage. The liver plays a crucial role in energy production by filtering toxins and storing nutrients. When it becomes damaged from opioid use, it struggles to perform these tasks, leading to overall weakness and tiredness. This persistent fatigue can significantly affect daily life and should not be ignored.
Nausea
Nausea is a common symptom of liver dysfunction. As the liver becomes overwhelmed and damaged by opioid use, it may struggle to break down toxins, which can cause nausea. This sensation often worsens after eating or taking certain medications. If nausea persists or becomes more frequent, it could indicate a problem with liver health and should be checked by a healthcare professional.
Dark Urine
Dark urine can be a sign that the liver is not processing waste properly. When the liver is damaged, it may release excess bilirubin into the bloodstream, which is then filtered by the kidneys and passed out in the urine. This causes the urine to turn dark brown or tea colored. If you notice this change in your urine, it’s important to seek medical attention as it could indicate liver damage.

Ways to Protect Your Liver
The following steps can help protect your liver and reduce the risks associated with opioid use.
Follow Your Doctor’s Instructions
Protecting from the effect of opioids on the liver starts with responsible use of these drugs. If you’re prescribed opioids, make sure to follow your doctor’s instructions carefully. Avoid taking more than the recommended dose and never mix opioids with alcohol or other substances, as this can greatly increase the risk of liver damage.
Consider Taking Breaks from Opioids
It’s also helpful to take breaks from opioids when possible. If you’re using them for pain relief, talk to your doctor about alternative pain management options. Reducing opioid use or exploring different treatments can help lower the risk of liver damage while still addressing your health needs.
Adopt a Healthy Lifestyle
Lifestyle changes can also support liver health. Eating a balanced diet, staying hydrated, and exercising regularly can help your liver function properly. Avoiding fatty foods and limiting processed foods can also take some stress off the liver and help it recover from any potential damage caused by opioid use.
Seek Professional Treatment
In 2021, approximately 2.5 million U.S. adults aged 18 and older had opioid use disorder. If you’re concerned about your opioid use, too, or about the effect of opioids on the liver, seeking treatment is crucial. A drug rehab in Palm Beach can provide support for managing opioid addiction and protecting your health. Professional care can guide you on the path to better health.

Get Help Early to Protect Your Liver
Taking care of your liver now can save you from serious health issues in the future. With more people struggling with opioid crisis, liver health is becoming a growing concern. If you’re struggling with opioid use or are worried about the risk of liver damage, it’s important to seek help early. Getting the support you need now can protect your liver and overall health long-term.
The Effect of Opioids on the Liver: What You Should Know for Better Health
Understanding the effect of opioids on the liver is important for anyone using these medications, especially over the long term. Opioids can cause significant liver damage if not used responsibly, leading to conditions like fatty liver disease and cirrhosis. Recognizing the signs of liver damage early can help prevent more severe health issues. By following medical advice, adopting a healthy lifestyle, and seeking professional treatment, you can protect your liver and overall health.
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